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Alprazolam extended release formulation (Alprazolam XR) is a new formulation with useful features in the treatment of pathological anxiety, when compared both to the original formulation of alprazolam or to other benzodiazepines, as it adds to the well known properties of alprazolam a sustained clinical effect. The available investigational clinical trials show good efficacy for this new formulation. There is the need, however, of observational studies in the clinical setting that confirm its usefulness. METHODS: We present an observational prospective naturalistic study of all the pathological anxiety cases that followed treatment with Alprazolam XR in two psychiatry outpatient centres. Sixty-eight (68) patients were included in the study. The treatment period was 21 weeks. In each of the 4 control visits, efficacy (HAMA, GCI, GCI improvement) and tolerability (adverse events) were assessed, as well as the dose, dosage pattern and need of change of the medication. RESULTS: Global anxiety (HAMA, GCI and CGI improvement) showed a significant reduction throughout the study. There was a reduction in the number of panic attacks> and in the severity of agoraphobia. Global clinical impression (efficacy and tolerability) was good or very good in 75% of the patients, both assessed by the investigator and by the patient. Fifty percent (50%) of the patients had an adverse event (mainly sedation), most cases being mild and transient. Fifty-eight percent (58%) of the patients needed a change in the dosage regimen (dose, number of daily doses), mostly due to clinical dose adjustment. Some patients needed a change in the dosage due to adverse events. Sixteen patients that had been treated with the conventional formulation of alprazolam and started treatment with Alprazolam XR needed a slightly higher dose of the extended release formulation. In these cases the change of medication was easy. CONCLUSION: The clinical use of Alprazolam XR in the treatment of pathological anxiety was useful in most of the patients (75%). The dose regime was usually 2-3 mg in two daily doses, with a trend to lower the dose (1-2 mg in a single dose) in the third or fourth control. The change from the conventional formulation to the extended release was not difficult in most of the patients.
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The most common side effect is sedation, but this often decreases or goes away in most people after their bodies get used to the drug. Until you experience how XANAX XR affects you, do not drive a car or operate potentially dangerous machinery, etc. Other common side effects, which occur in fewer patients, include sleepiness, memory impairment, impaired speech, abnormal coordination and/or muscle action, and reduced sexual drive. Some patients may experience side effects associated with psychological and/or physical dependence on XANAX XR. Medications like XANAX XR, even when used as recommended, may produce psychological and/or physical dependence. This may make it very difficult to discontinue treatment with XANAX XR. Discontinuation symptoms, including the possibility of seizures, may occur following abrupt discontinuation from any dose, but the risk may be increased with extended use at doses greater than 4 mg/day. It is important that you get your doctor’s advice on how to discontinue treatment safely and carefully. Gradually tapering your XANAX XR dose will help to decrease the possibility of discontinuation symptoms.
Symptom Relief. XANAX XR is a prescription medicine proven effective in the treatment of patients with panic disorder with or without agoraphobia. It boosts the effects of GABA, a natural chemical in your body that sends messages to your brain that tell it to “calm down.”
Once-a-Day Convenience. XANAX XR gives you the benefits of a benzodiazepine to treat panic disorder, in a once-daily formula. You won’t have to “watch the clock” or worry about where you’ll be when you have to take your next dose. And that can help you relax.
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All Day Relief. Most benzodiazepines have to be taken 2 to 4 times within 24 hours for all day relief. With other medicines, you may feel calm after you take the medicine but then lose that feeling before it’s time to take the next dose.
Advanced Formula. XANAX XR is a long-acting formulation of XANAX® (alprazolam), the most prescribed medication of its kind in the United States.